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NIAGEN® NR Therapy | Prime IV
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Patented · 28+ Clinical Trials · Pharmaceutical Grade

NIAGEN ®
The Smarter
Path to NAD+

NIAGEN® is the only patented, clinically validated form of Nicotinamide Riboside — the most bioavailable and most thoroughly studied NAD+ precursor available, now delivered directly into your bloodstream for maximum effect.

28+ Human RCTs 2.7× NAD+ Increase Cardiovascular Health Faster Sessions
Book Your Session See the Science

IV Delivery

NIAGEN® enters bloodstream instantly

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Cell Uptake

NR crosses cell membranes directly

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Phosphorylation

NR kinase converts NR → NMN inside cell

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NAD+ Synthesis

NMN becomes bioactive NAD+ in mitochondria

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Cellular Power

NAD+ fuels sirtuins, PARP & ATP production

2.7× Peak increase in blood NAD+ levels documented
28+ Published human clinical trials on NIAGEN®
1–2h Shorter, gentler infusion vs standard NAD+
10yr Equivalent cardiovascular age reduction in RCT
What Is NIAGEN®?

NAD+ can't get into your cells.
NIAGEN® can.

Here's a key challenge with direct NAD+ supplementation — NAD+ molecules are too large and chemically fragile to enter your cells intact. Your body must build NAD+ from precursor molecules that can actually cross cell membranes and be converted inside.

NIAGEN® is Nicotinamide Riboside (NR) — a natural form of Vitamin B3 that your cells readily accept and rapidly convert into NAD+. It is the most direct, most studied, and most bioavailable NAD+ pathway known to science. When delivered via IV at Prime IV Reston, it achieves near-instant systemic distribution.

Developed and patented by ChromaDex Corporation, NIAGEN® is the exact form of NR used in all published clinical trials — not a generic copy. Every batch is third-party verified for purity and potency.

Why NIAGEN® — Not Generic NR or Direct NAD+
✓

Crosses cell membranes directly — NR is a small, stable molecule that enters cells via NR transport proteins and is converted to NAD+ inside the mitochondria.

✓

28+ peer-reviewed human trials — Studies from Harvard, Dartmouth, and University of Colorado confirm safety and documented NAD+ elevation.

✓

Raises NAD+ by up to 2.7× — A 2016 Cell Metabolism study (Trammell et al.) confirmed NIAGEN® more than doubles blood NAD+ in healthy adults.

✓

Pharmaceutical-grade purity — Third-party tested. No fillers, no contaminants, no guesswork.

✗

Generic NR — Unpatented, unverified purity, variable potency. May not be the structural isomer that research is based on.

NIAGEN® is GRAS-affirmed (Generally Recognized as Safe) by the FDA — the highest safety designation for a nutritional ingredient.

Clinically Documented Benefits

Six Reasons Your Body Needs NIAGEN®

01
Explosive, Lasting Energy

By restoring NAD+ to youthful levels, NIAGEN® supercharges your mitochondria. Unlike caffeine, which temporarily borrows energy, this creates more actual cellular fuel. Clinical trials show significant, sustained reductions in fatigue scores.

Martens et al., Nature Communications 2018
02
Sharp, Clear Mind

NAD+ is essential for brain cell energy metabolism and neuroprotection. NIAGEN® has been studied for cognitive support in aging populations, with emerging data linking higher NAD+ to improved working memory and processing speed.

Brakedal et al., Cell Metabolism 2022
03
Cardiovascular Health

A 2018 University of Colorado RCT showed NIAGEN® improved arterial flexibility in middle-aged and older adults — equivalent to an estimated 10-year reduction in cardiovascular age. This is among the strongest human data for any NAD+ precursor.

Martens et al., Nature Communications 2018
04
Muscle & Recovery

NAD+ powers muscle stem cells and mitochondrial function in muscle tissue. NIAGEN® has shown improvements in muscle NAD+ levels, supporting faster recovery, reduced soreness, and better physical performance in clinical settings.

Conze et al., Scientific Reports 2019
05
Longevity Activation

Sirtuins (SIRT1–SIRT7) are your longevity proteins — they repair DNA, reduce inflammation, and regulate gene expression. They require NAD+ as fuel. NIAGEN® activates SIRT1 pathways, triggering cellular repair mechanisms associated with healthy aging.

Canto et al., Cell Metabolism 2012
06
Reduced Inflammation

Chronic inflammation is a primary driver of age-related decline. A 2022 clinical trial found NIAGEN® significantly reduced systemic inflammatory markers. Its effect on SIRT1 directly suppresses NF-κB, the master switch of the inflammatory response.

Brakedal et al., Cell Metabolism 2022
Side-by-Side

NIAGEN® vs Direct NAD+ IV

Both are powerful — and our team offers both. Here's an honest comparison to guide your protocol discussion.

Feature NIAGEN® (NR) Direct IV NAD+
Intracellular delivery ✓ Enters cells directly via transport proteins ~ Requires conversion at cell surface
Session duration ✓ 1–2 hours ✗ 4–6 hours
Human clinical trials ✓ 28+ published RCTs ~ Primarily observational data
Infusion comfort ✓ Smooth, gentle throughout ~ May cause transient flushing if too fast
Cardiovascular evidence ✓ RCT data on arterial stiffness ✗ Limited human data
Best suited for Regular maintenance, longevity protocol, first-time clients, cardiovascular support Acute energy restoration, high-dose loading, recovery support
Boosting NAD+ levels in older animals can ameliorate a wide range of age-associated health problems... The promise is that the same thing may happen in humans.
— Dr. David Sinclair, Professor of Genetics, Harvard Medical School · Cell, 2015
Your NIAGEN® Visit

A Smoother Journey to Cellular Renewal

NIAGEN® sessions are notably shorter and gentler than traditional NAD+ infusions, making them easy to fit into your schedule — even on a workday.

Before You Arrive

Personalized Intake & Protocol Design

Complete a brief online wellness intake. Our licensed nursing staff reviews your goals, health history, and current wellness status to design your NIAGEN® protocol — including dosage and complementary add-ins such as glutathione, B-complex, or Vitamin C.

At the Lounge

Zero-Gravity Chair & Spa Atmosphere

You're welcomed into our premium IV lounge at Reston Station. Your line is placed with minimal discomfort by one of our licensed RNs. NIAGEN® infusions are notably smoother than direct NAD+ — most clients remain completely comfortable and relaxed throughout.

During (1–2 Hours)

Relax, Work, or Rest

Unlike longer NAD+ infusions, a NIAGEN® session fits comfortably into a lunch break. Stream content, take calls on your laptop, or simply rest. Many clients notice a gentle warmth and mental clarity beginning within the first 30–60 minutes.

24–72 Hours After

The Results Unfold

Enhanced energy, clearer cognition, and improved physical performance are the most commonly reported benefits in the days following treatment. Cumulative sessions over weeks and months produce the most dramatic and lasting changes.

Common Questions

Frequently Asked Questions

What makes NIAGEN® different from generic NR? +
NIAGEN® is the patented, original form of Nicotinamide Riboside developed by ChromaDex Inc. It is the specific compound used in all 28+ published clinical trials. Generic NR products may use different structural isomers, have unverified purity, or lack any third-party testing. When we say NIAGEN®, you're getting the exact research-grade compound — not a copycat.
Is NIAGEN® or direct NAD+ better for me? +
Both are excellent — they work through complementary mechanisms. NIAGEN® is ideal for regular longevity maintenance, first-time clients, shorter sessions, and those particularly focused on cardiovascular health. Direct NAD+ is often preferred for high-dose loading or acute recovery. Our clinical staff will help you determine the best protocol — or a combination of both — during your consultation.
Is the cardiovascular benefit real? +
Yes — this is one of NIAGEN®'s most compelling findings. A 2018 randomized controlled trial at the University of Colorado (Martens et al., Nature Communications) found that NIAGEN® supplementation for 6 weeks reduced aortic stiffness in middle-aged and older adults — equivalent to approximately 10 years of cardiovascular age reversal. This is placebo-controlled, peer-reviewed human data.
How many sessions do I need? +
For a longevity maintenance protocol, we typically recommend 2 sessions per month initially, tapering to once monthly as a maintenance schedule. Because sessions are shorter than traditional NAD+ infusions, they integrate easily into regular routines. Your protocol will be fully personalized during your intake consultation.
Does Prime IV Reston offer membership discounts for NIAGEN®? +
Yes. Our Transformation membership plan includes access to premium drips including NIAGEN® IV, along with maximum retail discounts, priority booking, and exclusive event access. Speak with our team or visit our memberships page to find the plan that fits your wellness goals.

The Most Studied NAD+ Precursor.
Now Available in Reston.

Schedule your NIAGEN® session at Prime IV Reston and discover the difference that pharmaceutical-grade, clinically validated NAD+ support can make in how you feel, think, and perform.

Book Your NIAGEN® Session

Medical Disclaimer: The information on this page is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease or medical condition. NIAGEN® IV therapy is a wellness service. Individual results vary. Scientific references cited reflect published peer-reviewed research; outcomes in IV wellness settings may differ. NIAGEN® is a registered trademark of ChromaDex, Inc. Consult your healthcare provider before beginning any new health protocol. Prime IV Hydration & Wellness – Reston | 11209 Reston Station Blvd, Reston, VA 20190 | (571) 200-5063

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